xi'an land nutra co.,ltd 
Description of Berberine Hcl Powder:
Berberine, also known as yellow cypressine, is a quaternary ammonium alkaloid isolated from the Chinese herb Coptis chinensis. It is the primary active ingredient responsible for the antibacterial properties of Coptis chinensis. Appearing as yellow needle-like crystals with a bitter taste, The plant kingdom widely distributes berberine, which approximately 10 genera across 4 families contain.
Specification of Berberine Hcl Powder：
| Product Name | Berberine Hcl |
|---|---|
| Item | Standard |
| Grade | Food Grade |
| Specification | 99% minimum |
| Appearance | Yellow Powder |
| Shelf Life | 24 months |
| Storage | Keep in a cool, dry place |
Benefits of Berberine Hcl Powder：
- Antibacterial and anti-inflammatory: It has a significant inhibitory effect on a variety of bacterial and fungal infections
- Antiviral: It has an inhibitory effect on influenza virus, hepatitis B virus and other viruses.
- Antihypertensive and hepatoprotective: By inhibiting vasoconstriction and improving blood circulation, it can lower blood pressure and protect the liver at the same time.
- Antioxidant: Reduces cell damage caused by free radicals and improves immunity.
- Others: Recent studies have also found that berberine hydrochloride has a variety of potential effects, such as anti-tumor, anti-obesity, and anti-diabetes.
Applications of Berberine Hydrochloride:
Pharmaceutical field: Doctors use it to treat a variety of infectious diseases due to its antibacterial and anti-inflammatory properties. They also use it for its potential benefits in lowering blood sugar and cholesterol levels
Food industry: as a natural preservative, to extend the shelf life of food, and improve the flavor of some foods.
Health care industry: Manufacturers often add it to health care products because it has been shown to improve immunity and act as an antioxidant.
Cosmetic industry: Due to its antioxidant effect, it is used in skin care products to delay skin aging.
Industry: As dye intermediates and chemical reagents, it plays a role in industrial production.
| Item | Specification | Result | Compliance | Remarks |
|---|---|---|---|---|
| Berberine Hydrochloride Content | ≥ 95% | 95.05% | Compliant | Slightly above the minimum limit, indicating high purity. |
| Appearance | Yellow powder | Compliant | Consistent with the standard. | |
| Odor | Characteristic odor | Compliant | Indicates no significant impurities. | |
| Mesh Size | 100% passes 80 mesh | Compliant | Uniform particle size, easy to disperse. | |
| Ash Content | ≤ 5.0% | 3.12% | Compliant | Low ash content indicates fewer inorganic impurities. |
| Loss on Drying | ≤ 5.0% | 3.42% | Compliant | Low moisture content, beneficial for long-term storage. |
Microbiological Tests
| Item | Specification | Result | Compliance | Remarks |
|---|---|---|---|---|
| Total Plate Count | ≤ 1000 cfu/mg | Compliant | Indicates a low total number of bacteria and fungi. | |
| Yeast and Mold | ≤ 25 cfu/mg | Compliant | Indicates good control of mold contamination. | |
| E. coli | ≤ 40MPN/100g | Compliant | Indicates good control of fecal contamination. | |
| Staphylococcus aureus | Negative | Compliant | Indicates the absence of Staphylococcus aureus. |
Scientists extract berberine hydrochloride and dihydroberberine, which are alkaloids, from Berberis vulgaris. These alkaloids have similar pharmacological effects, However, dihydroberberine is a hydrogenated derivative of berberine hydrochloride, with two more hydrogen atoms in its structure.
The main difference is:
Bioavailability: Dihydroberberine’s significantly higher bioavailability than berberine hydrochloride means the body more easily absorbs and utilizes it.
Efficacy: Dihydroberberine is more effective in improving insulin sensitivity and blood glucose control, and has fewer side effects.
